Genomics and Causal Inference

led by Golam Khandaker and Tom Gaunt in Bristol, this workstream will use Mendelian randomization and other genetic analyses to screen a large number of inflammatory proteins for a causal relationship to severe mental illness.

led by Andrew McIntosh and Xueyi Shin in Edinburgh, this workstream will use Mendelian randomization and other genetic analyses to screen a large number of metabolic proteins for a causal relationship to severe mental illness.

led by Mary-Ellen Lynall in Cambridge, with the IMRB in Paris as a key partner, this workstream will use single cell RNA sequencing and other data to find immune cell types that mediate risk for severe mental illness.